Objectives: To report our experience in treatment and course of patients\r\nhad BK virus infections following kidney transplantation in our center.\r\nMethods: We evaluated four renal transplant patients with BKVN\r\namong the patients transplanted and followed in our clinic in between\r\n2000 ââ?¬â?? 2010. We screened the presence of plasma and urine BK virus\r\nDNA by quantitative real-time polymerase chain reaction in renal\r\ntransplant recipients with graft dysfunction and evaluated evidence of\r\nBK virus nephropathy (BKVN) in their graft biopsy specimens.\r\nResults: Overall, four patients were studied (mean age was13.5 years;\r\nmean donor age was 26.5 years). In all patients in plasma BK virus\r\nDNA was detected. Time elapsed from transplantation to BKVN\r\ndiagnosis ranged from 3 to 24 months. We reduced their\r\nimmunosuppressive drugs and also IVIG treatment (2g/kg/day) was\r\nadministered in two patients (patient 1 and 4). The all grafts are still\r\nfunctioning with a mean creatinine level of 1.15 mg/dl.\r\nConclusions: Early diagnosis of BKV infection with reduction of\r\nimmunosuppression may potentially counter BK viremia and retard\r\nprogression of BKV nephropathy.
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